CAS COVID-19 Resources

Knowledge Graphs Accelerate COVID-19 Therapies

This whitepaper details the CAS Biomedical Knowledge Graph and shows how it was used in drug discovery for COVID-19.

Knowledge Graphs Accelerate COVID-19 Therapies

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Review of Global Efforts on COVID-19 Vaccine Development

This report reviews Covid-19 vaccine research, compares the underlying technologies, the use of adjuvants and delivery systems in their application, and provides a perspective on their future direction.

Review of the Global Efforts on COVID-19 Vaccine Development

Covid-19 Vaccine Breakthroughs

This whitepaper explores the innovative research and technologies that played a crucial role in the development of Covid-19 vaccines.

COVID-19 Vaccine Breakthroughs

QSAR Machine Learning Models and their Applications for Identifying Potential COVID-19 Therapeutics

To identify potential anti-SARS-CoV-2 therapeutics, CAS scientists are building machine-learning predictive models to identify novel drug candidates for the viral targets 3 chymotrypsin-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp).

QSAR Machine Learning Models for Identifying Covid-19 Therapeutics

Potential Therapeutics and Associated Bioassay Data for COVID-19

To support ongoing research and development of COVID-19 therapeutics, this report provides an overview of protein targets and corresponding potential drug candidates with bioassay and structure-activity relationship data found in the scientific and patent literature for COVID-19.

Potential Therapeutics and Associated Bioassay Data for COVID-19

CAS COVID-19 Bioindicator Explorer

The CAS COVID-19 Bioindicator Explorer uses data extracted from our comprehensive journal and patent collection to identify correlations between drug-like substances with antiviral activity and COVID-19 protein targets.

CAS COVID-19 Bioindicator Explorer

CAS COVID-19 Antiviral Candidate SAR Dataset

This open source dataset contains over 290K structure-activity relationship (SAR) data directed at COVID-19 protein, virus and disease targets reported in the literature, patents, and other public sources for over 9K of the substances included in the CAS COVID-19 Antiviral Candidate Compounds Dataset.

COVID-19 Antiviral Candidate SAR Dataset

Assay Techniques and Test Development for COVID-19 Diagnosis

To provide an understanding and comparison of the diagnostic tests available in the fight against COVID-19, this CAS report summarizes the basic principles of molecular and serological assays being used in diagnostic tests for SARS-CoV-2. The report highlights advancements in testing technologies and provides a look at currently available diagnostic tests.

Assay Techniques and Test Development for COVID-19 Diagnosis

CAS COVID-19 Protein Target Thesaurus

This collection of human-curated protein targets and their synonyms from CAS REGISTRY^® and the CAS Thesaurus provides additional points of discovery to supplement your research.

CAS COVID-19 Protein Target Thesaurus

CAS COVID-19 Antiviral Candidate Dataset

The open source dataset of nearly 50K chemical substances includes antiviral drugs and related compounds that are structurally similar to known antivirals for use in applications including research, data mining, machine learning, and analytics.

CAS COVID-19 Antiviral Candidate Compounds Dataset

Open Access Article: R&D of Therapeutics and Vaccines of COVID-19 and related diseases

This CAS special report provides a comprehensive overview of published scientific information highlighting antiviral strategies involving small molecules and biologics targeting complex molecular interactions. Published in ACS Central Science.

Research on Therapeutic Agents and Vaccines for COVID-19

Additional Resources

depiction of spike protein region on a Covid virus

Blog

Why the Omicron BA.5 Variant Evades Vaccines

As COVID-19 cases rise again worldwide, the Omicron subvariant BA.5 is currently the dominant strain. This blog explores some key mutations that …

Blog

Omicron variant accelerates need for more diverse COVID-19 vaccine strategy

Current vaccines against SARS-CoV-2 that target the spike protein are an important step toward developing antiviral therapeutics and next-generation …

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Blog

Coronavirus Variants: The Delta Variant and the Future Impact of Viral Mutations

If you are fully vaccinated, should you be worried about the impact of COVID-19 variants? Read this blog and learn about effectiveness of vaccines on …

Pfizer Covid Vaccine approved for 12-15 year olds

Blog

Latest data on the safety and effectiveness of COVID-19 vaccines in children

Information covering CDC recommendation of pediatric COVID-19 vaccine for children ages 5-11, and original emergency use authorization from May 2021 …

Blog

Do other vaccines protect you from COVID-19?

Quickly after the emergence of COVID-19, it became clear that vaccines and drugs would be needed to tackle the SARS-CoV-2 virus and bring an end to …

Blog

Building on “flu shot” success to tackle COVID-19

Pharmaceutical companies and public health officials are leveraging experience with the well-known influenza vaccine to support successful …

Blog

Taking aim at COVID-19’s most wanted targets

In support of ongoing research efforts to identify additional drugs for COVID-19, a team of CAS scientists analyzed published scientific information …